解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Intellectual disability (ID) is a measurable phenotypic consequence of genetic and environmental factors. In this study, we prospectively assessed the diagnostic yield of genomic tools (molecular karyotyping, multi-gene panel and exome sequencing) in a cohort of 337 ID subjects as a first-tier test and compared it wit...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.113
更新日期:2017-04-01 00:00:00
abstract::Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of CNTN5 and CNTN6 have previously been reported in individuals with autism spectrum disorders (ASDs), but very little is known on their prevalence and clinical impact....
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.61
更新日期:2017-04-01 00:00:00
abstract::The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathophysiology of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated HPA axis overactivity in major depression, a relationship of HPA axis activity to cognitive performance and a potential role of HPA axis geneti...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.120
更新日期:2017-04-01 00:00:00
abstract::Anxiety disorders constitute a major disease and social burden worldwide; however, many questions concerning the underlying molecular mechanisms still remain open. Besides the involvement of the major excitatory (glutamate) and inhibitory (gamma aminobutyric acid (GABA)) neurotransmitter circuits in anxiety disorders,...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.87
更新日期:2017-03-01 00:00:00
abstract::Identifying biological mechanisms through which the experience of adversity emerges as individual risk for mental illness is an important step toward developing strategies for personalized treatment and, ultimately, prevention. Preclinical studies have identified epigenetic modification of gene expression as one such ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.82
更新日期:2017-02-01 00:00:00
abstract::The lack of strong association between brain beta-amyloid deposition and cognitive impairment has been a challenge for the Alzheimer's disease (AD) field. Although beta-amyloid is necessary for the pathologic diagnosis of AD, it is not sufficient to make the pathologic diagnosis or cause dementia. We sought to identif...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.35
更新日期:2017-02-01 00:00:00
abstract::Recent studies have revealed that the gut microbiota modulates brain development and behavior, but the underlying mechanisms are still poorly understood. Here, we show that bacterial peptidoglycan (PGN) derived from the commensal gut microbiota can be translocated into the brain and sensed by specific pattern-recognit...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2016.182
更新日期:2017-02-01 00:00:00
abstract::While localizing sensory and motor deficits is one of the cornerstones of clinical neurology, behavioral and cognitive deficits in psychiatry remain impervious to this approach. In psychiatry, major challenges include the relative subtlety by which neural circuits are perturbed, and the limited understanding of how ba...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2016.183
更新日期:2017-02-01 00:00:00
abstract::Research on avoidance conditioning began in the late 1930s as a way to use laboratory experiments to better understand uncontrollable fear and anxiety. Avoidance was initially conceived of as a two-factor learning process in which fear is first acquired through Pavlovian aversive conditioning (so-called fear condition...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2016.166
更新日期:2017-01-01 00:00:00
abstract::The 'neurodegeneration with brain iron accumulation' (NBIA) disease family entails movement or cognitive impairment, often with psychiatric features. To understand how iron loading affects the brain, we studied mice with disruption of two iron regulatory genes, hemochromatosis (Hfe) and transferrin receptor 2 (Tfr2). ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.192
更新日期:2016-11-01 00:00:00
abstract::In recent years, numerous studies of gene regulation mechanisms have emerged in neuroscience. Epigenetic modifications, described as heritable but reversible changes, include DNA methylation, DNA hydroxymethylation, histone modifications and noncoding RNAs. The pathogenesis of psychiatric disorders, such as bipolar di...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2016.123
更新日期:2016-11-01 00:00:00
abstract::The current study provides a novel in-depth assessment of the extent of antipsychotic drugs transport across the blood-brain barrier (BBB) into various brain regions, as well as across the blood-spinal cord barrier (BSCB) and the blood-cerebrospinal fluid barrier (BCSFB). This is combined with an estimation of cellula...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.229
更新日期:2016-11-01 00:00:00
abstract::Critical periods are temporary windows of heightened neural plasticity early in development. For example, fear memories in juvenile rodents are subject to erasure following extinction training, while after closure of this critical period, extinction training only temporarily and weakly suppresses fear memories. Persis...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.179
更新日期:2016-09-01 00:00:00
abstract::A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memory reconsolidation represents a potential therapeutic strategy,...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.157
更新日期:2016-08-01 00:00:00
abstract::Positron emission tomography (PET) studies suggest opioidergic system dysfunction in morbid obesity, while evidence for the role of the dopaminergic system is less consistent. Whether opioid dysfunction represents a state or trait in obesity remains unresolved, but could be assessed in obese subjects undergoing weight...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.153
更新日期:2016-08-01 00:00:00
abstract::Abnormalities in prefrontal gamma aminobutyric acid (GABA)ergic transmission, particularly in fast-spiking interneurons that express parvalbumin (PV), are hypothesized to contribute to the pathophysiology of multiple psychiatric disorders, including schizophrenia, bipolar disorder, anxiety disorders and depression. Wh...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.222
更新日期:2016-07-01 00:00:00
abstract::Genomic risk profile scores (GRPSs) have been shown to predict case-control status of schizophrenia (SCZ), albeit with varying sensitivity and specificity. The extent to which this variability in prediction accuracy is related to differences in sampling strategies is unknown. Danish population-based registers and Neon...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.130
更新日期:2016-07-01 00:00:00
abstract::Inbreeding depression refers to lower fitness among offspring of genetic relatives. This reduced fitness is caused by the inheritance of two identical chromosomal segments (autozygosity) across the genome, which may expose the effects of (partially) recessive deleterious mutations. Even among outbred populations, auto...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.120
更新日期:2016-06-01 00:00:00
abstract::Latency-reversing agents (LRAs), including histone deacetylase inhibitors (HDACi), are being investigated as a strategy to eliminate latency in HIV-infected patients on suppressive antiretroviral therapy. The effectiveness of LRAs in activating latent infection in HIV strains derived from the central nervous system (C...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.111
更新日期:2016-04-01 00:00:00
abstract::Cognitive impairment is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that some aspects of intelligence are preserved or even superior in people with ASD compared with controls, but consistent evidence is lacking. Few s...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.12
更新日期:2016-03-01 00:00:00
abstract::Psychotropic medications target glycogen synthase kinase 3β (GSK3β), but the functional integration with other factors relevant for drug efficacy is poorly understood. We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3β at serine 9 (pGSK3β(S9))....
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.38
更新日期:2016-02-01 00:00:00
abstract::Peripheral blood brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker related to disease activity and neuroprogression in bipolar disorder, speculated to mirror alterations in brain expression of BDNF. The research area is rapidly evolving; however, recent investigations have yielded con...
journal_title:Molecular psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1038/mp.2015.54
更新日期:2016-02-01 00:00:00
abstract::Previous studies have shown inconsistent results regarding the actions of antidepressants on glucocorticoid receptor (GR) signalling. To resolve these inconsistencies, we used a lentiviral-based reporter system to directly monitor rat hippocampal GR activity during stress adaptation. Temporal GR activation was induced...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.137
更新日期:2016-02-01 00:00:00
abstract::Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and sex using a 51-plex cyto...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.29
更新日期:2016-02-01 00:00:00
abstract::Depression is a common debilitating human disease whose etiology has defied decades of research. A critical bottleneck is the difficulty in modeling depressive episodes in animals. Here, we show that a transgenic mouse with chronic forebrain expression of a dominant negative mutant of Polg1, a mitochondrial DNA (mtDNA...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.156
更新日期:2016-01-01 00:00:00
abstract::Accumulating research demonstrates the potential of intranasal delivery of psychopharmacological agents to treat a range of psychiatric disorders and symptoms. It is believed that intranasal administration offers both direct and indirect pathways to deliver psychopharmacological agents to the central nervous system. T...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2015.166
更新日期:2016-01-01 00:00:00
abstract::Serotonergic (5HT) neurons exert diverse and widespread functions in the brain. Dysfunction of the serotonergic system gives rise to a variety of mental illnesses including depression, anxiety, obsessive compulsive disorder, autism and eating disorders. Here we show that human primary fibroblasts were directly convert...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.101
更新日期:2016-01-01 00:00:00
abstract::This study explores whether inflammatory biomarkers act as moderators of clinical response to omega-3 (n-3) fatty acids in subjects with major depressive disorder (MDD). One hundred fifty-five subjects with Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) MDD, a baseline 17-item Hamilton Dep...
journal_title:Molecular psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/mp.2015.22
更新日期:2016-01-01 00:00:00
abstract::Depression often accompanies the perimenopausal transition and it often precedes overt symptomology in common neurodegenerative diseases (NDDs, such as Alzheimer's, Parkinson's, Huntington, amyotrophic lateral sclerosis). Serotonin dysfunction is frequently found in the different etiologies of depression. We have show...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.178
更新日期:2015-12-01 00:00:00
abstract::Adults with psychotic disorders have dysconnectivity in critical brain networks, including the default mode (DM) and the cingulo-opercular (CO) networks. However, it is unknown whether such deficits are present in youth with less severe symptoms. We conducted a multivariate connectome-wide association study examining ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.66
更新日期:2015-12-01 00:00:00
abstract::The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed within the central nervous system. Previous work showed that this protein is upregulated in Alzheimer's disease (AD), and plays an active role in the development of brain amyloidosis in amyloid beta (Aβ)-precursor protein transgenic mice (Tg2576). In the pr...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.170
更新日期:2015-11-01 00:00:00
abstract::Exercise has a variety of beneficial effects on brain structure and function, such as hippocampal neurogenesis, mood and memory. Previous studies have shown that exercise enhances hippocampal neurogenesis, induces antidepressant effects and improves learning behavior. Brain serotonin (5-hydroxytryptamine, 5-HT) levels...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.153
更新日期:2015-11-01 00:00:00
abstract::Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each transmitter in the regulatio...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2015.104
更新日期:2015-11-01 00:00:00
abstract::The prefrontal cortex (PFC), seat of the highest-order cognitive functions, constitutes a conglomerate of highly specialized brain areas and has been implicated to have a role in the onset and installation of various neurodevelopmental disorders. The development of a properly functioning PFC is directed by transcripti...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2014.147
更新日期:2015-07-01 00:00:00
abstract::Previous studies suggested that risk for Autism Spectrum Disorder (ASD) may be increased in children exposed to antidepressants during the prenatal period. The disease specificity of this risk has not been addressed and the possibility of confounding has not been excluded. Children with ASD or attention-deficit hypera...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.90
更新日期:2015-06-01 00:00:00
abstract::Endogenous opioid and non-opioid mechanisms (for example, dopamine (DA), endocannabinoids (eCB)) have been implicated in the formation of placebo analgesic effects, with initial reports dating back three decades. Besides the perspective that placebo effects confound randomized clinical trials, the information so far a...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2014.164
更新日期:2015-04-01 00:00:00
abstract::Post-traumatic stress disorder (PTSD) is associated with elevated risk for a variety of age-related diseases and neurodegeneration. In this paper, we review evidence relevant to the hypothesis that chronic PTSD constitutes a form of persistent life stress that potentiates oxidative stress (OXS) and accelerates cellula...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2014.111
更新日期:2014-11-01 00:00:00
abstract::Circulating triglycerides (TGs) normally increase after a meal but are altered in pathophysiological conditions, such as obesity. Although TG metabolism in the brain remains poorly understood, several brain structures express enzymes that process TG-enriched particles, including mesolimbic structures. For this reason,...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.31
更新日期:2014-10-01 00:00:00
abstract::The GRIA1 locus, encoding the GluA1 (also known as GluRA or GluR1) AMPA glutamate receptor subunit, shows genome-wide association to schizophrenia. As well as extending the evidence that glutamatergic abnormalities have a key role in the disorder, this finding draws attention to the behavioural phenotype of Gria1 knoc...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2014.91
更新日期:2014-10-01 00:00:00
abstract::Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy number variations (CNVs) in SCZ cases and identified multiple rare recurrent CNVs that increase risk of SCZ although with incomplete penetranc...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2014.40
更新日期:2014-07-01 00:00:00